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Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and so it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular could be the fact that since right now there aren't any long term prescription weightloss pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be licensed by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug also can raise blood pressure and heart rate, and shouldn't be used in individuals with a history of cardiac event or stroke in the earlier six months. 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